Optimization, Fabrication and Characterization of Novel Meloxicam-Loaded Surface Attached Solid Dispersions to Ameliorate its Aqueous Solubility and Dissolution Employing Spray-Drying Technique

Objective: To formulate unmodified crystalline meloxicam solid dispersions by the use of surfactants and polymer. This polymeric particulate system is named as meloxicam-loaded surface attached dispersion (MSDs). Methodology: experimental study was conducted at Lab Physical Industrial Pharmacy, Hanyang University, South Korea. The duration this around seven months. first phase (optimization fabrication) completed within 3 months, while, solubility, dissolution physicochemical characterization in next 4 These surfaces were prepared using spray drying technology. Moreover, HPMC SLS used hydrophilic carriers. Various MSDs carriers/drug, evaluated for aqueous solubility studies. Results: Amongst different formulation prepared, MSDs3 having Meloxicam/HPMC/SLS a (1:0.5:0.5) gave highest (i.e. from 0.25 ±0.17ug/ml to 153 ±5.3ug/ml). enhanced 2.96 ±0.55% 47 ±1.07% 15 minutes. Furthermore, performed scanning electron microscopy (SEM), differential calorimetry (DSC) powder X-ray diffraction (PXRD). Conclusion: In conclusion we can predict better dispersion. Keywords: Meloxicam, enhancement, drying, attached,